PT - JOURNAL ARTICLE AU - Masa Tsuchiya AU - Alessandro Giuliani AU - Kenichi Yoshikawa TI - Underlying Genomic Mechanism for Cell-Fate Change from Embryo to Cancer Development AID - 10.1101/637033 DP - 2019 Jan 01 TA - bioRxiv PG - 637033 4099 - http://biorxiv.org/content/early/2019/05/14/637033.short 4100 - http://biorxiv.org/content/early/2019/05/14/637033.full AB - Through our studies on whole genome regulation, we have demonstrated the existence of self-organized critical control (SOC) of whole gene expression at both the cell population and single cell level. In this paper, we go further in depth into the elucidation of general genomic mechanism that underlies the cell-fate change from embryo to cancer development.In both single-cell and cell-population genome expression, a systematic determination of critical point (CP) and associated critical states with dynamical pictures for between-state flux provide a potential universal mechanism of self-organization in terms of ‘genome-engine’. An autonomous critical control system is developed by a highly coherent behavior of low-variance genes (sub-critical state) generating a dominant cyclic expression flux with high-variance genes (super-critical state) through the cell nuclear environment. To determine when and how cell-fate decision occurs under the SOC mechanism, the coherent dynamics on the genome-engine are working through the dynamic transition of higher-order structure of genomic DNA (corresponding to the CP), which causes either an activated (ON) or inactivated (OFF) state in a self-organized manner.