RT Journal Article
SR Electronic
T1 CA2 Neuronal Activity Controls Hippocampal Oscillations and Social Behavior
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 190504
DO 10.1101/190504
A1 Georgia M. Alexander
A1 Logan Y. Brown
A1 Shannon Farris
A1 Daniel Lustberg
A1 Caroline Pantazis
A1 Bernd Gloss
A1 Nicholas W. Plummer
A1 Natallia V. Riddick
A1 Sheryl S. Moy
A1 Patricia Jensen
A1 Serena M. Dudek
YR 2017
UL http://biorxiv.org/content/early/2017/12/28/190504.abstract
AB Hippocampal oscillations arise from coordinated activity among distinct populations of neurons and are associated with cognitive functions and behaviors. Although much progress has been made toward identifying the relative contribution of specific neuronal populations in hippocampal oscillations, far less is known about the role of hippocampal area CA2, which is thought to support social aspects of episodic memory. Furthermore, the little existing evidence on the role of CA2 in oscillations has led to conflicting conclusions. Therefore, we sought to identify the specific contribution of CA2 pyramidal neurons to brain oscillations using a controlled experimental system. We used excitatory and inhibitory DREADDs in transgenic mice to acutely and reversibly manipulate CA2 pyramidal cell activity. Here, we report on the role of CA2 in hippocampal-prefrontal cortical network oscillations and social behavior. We found that excitation or inhibition of CA2 pyramidal cells bidirectionally regulated hippocampal and prefrontal cortical low gamma oscillations and inversely modulated hippocampal ripple oscillations. Further, CA2 inhibition impaired social approach behavior. These findings support a role for CA2 in low gamma generation and ripple modulation within the hippocampus and underscore the importance of CA2 neuronal activity in extrahippocampal oscillations and social behavior.