RT Journal Article
SR Electronic
T1 Integrating proteomics and genomics into systems genetics provides novel insights into the mechanisms of drought tolerance in maize
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 636514
DO 10.1101/636514
A1 Blein-Nicolas, Mélisande
A1 Negro, Sandra Sylvia
A1 Balliau, Thierry
A1 Welcker, Claude
A1 Bosquet, Llorenç Cabrera
A1 Nicolas, Stéphane Dimitri
A1 Charcosset, Alain
A1 Zivy, Michel
YR 2019
UL http://biorxiv.org/content/early/2019/05/17/636514.abstract
AB The evolution of maize yields under drought is of particular concern in the context of climate change and human population growth. To better understand the mechanisms associated with the genetic polymorphisms underlying the variations of traits related to drought tolerance, we used a systems genetics approach integrating high-throughput phenotypic, proteomics and genomics data acquired on 254 maize hybrids grown under two watering conditions. We show that water deficit, even mild, induced a strong proteome remodeling and a reprogramming of the genetic control of the abundance of many proteins. We identify close colocalizations between QTLs and pQTLs, thus highlighting environment-specific pleiotropic loci associated to the co-expression of drought-responsive proteins and to the variations of phenotypic traits. These findings bring several lines of evidence supporting candidate genes at many loci and provide novel insight into the molecular mechanisms of drought tolerance.