PT - JOURNAL ARTICLE AU - Alina Baltus AU - Christoph Siegfried Herrmann TI - Transcranial alternating current stimulation modulates auditory temporal resolution in elderly people AID - 10.1101/241471 DP - 2017 Jan 01 TA - bioRxiv PG - 241471 4099 - http://biorxiv.org/content/early/2017/12/31/241471.short 4100 - http://biorxiv.org/content/early/2017/12/31/241471.full AB - Recent research provides evidence for a functional role of brain oscillations for perception. For example, auditory temporal resolution seems to be linked to individual gamma frequency of auditory cortex. Individual gamma frequency not only correlates with performance in between-channel gap detection tasks but can be modulated via auditory transcranial alternating current stimulation. Modulation of individual gamma frequency is accompanied by an improvement in gap detection performance. Aging changes electrophysiological frequency components and sensory processing mechanisms. Therefore, we conducted a study to investigate the link between individual gamma frequency and gap detection performance in elderly people using auditory transcranial alternating current stimulation. In a within-subject design, nine participants were electrically stimulated with two individualized transcranial alternating current stimulation frequencies: 3 Hz above their individual gamma frequency (experimental condition) and 4 Hz below their individual gamma frequency (control condition) while they were performing a between-channel gap detection task. As expected, individual gamma frequencies correlated significantly with gap detection performance at baseline and in the experimental condition, transcranial alternating current stimulation modulated gap detection performance. In the control condition, stimulation did not modulate gap detection performance. In addition, in elderly, the effect of transcranial alternating current stimulation on auditory temporal resolution seems to be dependent on endogenous frequencies in auditory cortex: elderlies with slower individual gamma frequencies and lower auditory temporal resolution profit from auditory transcranial alternating current stimulation and show increased gap detection performance during stimulation. Our results strongly suggest individualized transcranial alternating current stimulation protocols for successful modulation of performance.ASSRauditory steady state responseEEGelectroencephalographyERPevent related potentialGABAgamma-Aminobutyric acidGDgap detectionHzHertzIGFindividual gamma frequencymAmilliampereMFmodulation frequencymsmillisecondsPTApure tone audiometrytACStranscranial alternating current stimulation