PT  - JOURNAL ARTICLE
AU  - J. Alexander Bae
AU  - Shang Mu
AU  - Jinseop S. Kim
AU  - Nicholas L. Turner
AU  - Ignacio Tartavull
AU  - Nico Kemnitz
AU  - Chris S. Jordan
AU  - Alex D. Norton
AU  - William M. Silversmith
AU  - Rachel Prentki
AU  - Marissa Sorek
AU  - Celia David
AU  - Devon L. Jones
AU  - Doug Bland
AU  - Amy L. R. Sterling
AU  - Jungman Park
AU  - Kevin L. Briggman
AU  - H. Sebastian Seung
AU  - the EyeWirers
TI  - Digital museum of retinal ganglion cells with dense anatomy and physiology
AID  - 10.1101/182758
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 182758
4099  - http://biorxiv.org/content/early/2018/01/02/182758.short
4100  - http://biorxiv.org/content/early/2018/01/02/182758.full
AB  - Most digital brain atlases have macroscopic resolution and are confined to a single imaging modality. Here we present a new kind of resource that combines dense maps of anatomy and physiology at cellular resolution. The resource encompasses almost 400 ganglion cells from a single patch of mouse retina, and a digital “museum” provides a 3D interactive view of each cell’s anatomy as well as graphs of its visual responses. To demonstrate the utility of the resource, we use it to divide the inner plexiform layer of the retina into four sublaminae defined by a purely anatomical principle of arbor segregation. We also test the hypothesis that the aggregate neurite density of a ganglion cell type should be approximately uniform (“density conservation”). Finally, we find that ganglion cells arborizing in the inner marginal sublamina of the inner plexiform layer exhibit significantly more sustained visual responses on average.