PT  - JOURNAL ARTICLE
AU  - Ratnadeep Mukherjee
AU  - Diwakar Kumar Singh
AU  - Pijus Kanti Barman
AU  - Birendra Kumar Prusty
AU  - Pravat Thatoi
AU  - Rina Tripathy
AU  - Bidyut Kumar Das
AU  - Balachandran Ravindran
TI  - A novel polymorphism in nitric oxide synthase interacting protein (NOSIP) modulates nitric oxide synthesis and influences mortality in human sepsis
AID  - 10.1101/038398
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 038398
4099  - http://biorxiv.org/content/early/2018/01/04/038398.short
4100  - http://biorxiv.org/content/early/2018/01/04/038398.full
AB  - Nitric oxide performs a wide variety of versatile functions in the immune system. The precise role of nitric oxide in pathogenesis of acute inflammation and sepsis is still controversial. A direct physical interaction between inducible nitric oxide synthase (iNOS) and Nitric oxide synthase interacting protein (NOSIP) was observed that regulates Nitric Oxide production by human monocytes. A novel mutation in nitric oxide synthase interacting protein (NOSIP) determines NO levels and influence adverse prognosis and mortality in human sepsis. Differences in production of Nitric oxide by murine and human macrophages could be attributed to differential expression of NOSIP by the two species. The study reveals NOSIP as an important regulator of inflammation by virtue of its ability to influence nitric oxide production which inhibits IL-lβ levels in both mice and in humans and opens up novel avenues for therapeutic strategies against acute inflammation.