PT  - JOURNAL ARTICLE
AU  - Li, Chang
AU  - Swartz, Michael D.
AU  - Yu, Bing
AU  - Bai, Yongsheng
AU  - Liu, Xiaoming
TI  - dbMTS: a comprehensive database of putative human microRNA target site SNVs and their functional predictions
AID  - 10.1101/554485
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 554485
4099  - http://biorxiv.org/content/early/2019/05/26/554485.short
4100  - http://biorxiv.org/content/early/2019/05/26/554485.full
AB  - microRNAs (miRNAs) are short non-coding RNAs that can repress the expression of protein coding messenger RNAs (mRNAs) by binding to the 3’UTR of the target. Genetic mutations such as single nucleotide variants (SNVs) in the 3’UTR of the mRNAs can disrupt this regulatory effect. In this study, we presented dbMTS, the database for miRNA target site (MTS) SNVs, which includes all potential MTS SNVs in the 3’UTR of human genome along with hundreds of functional annotations. This database can help studies easily identify putative SNVs that affect miRNA targeting and facilitate the prioritization of their functional importance. dbMTS is freely available at: https://sites.google.com/site/jpopgen/dbNSFP.