RT Journal Article
SR Electronic
T1 dbMTS: a comprehensive database of putative human microRNA target site SNVs and their functional predictions
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 554485
DO 10.1101/554485
A1 Li, Chang
A1 Swartz, Michael D.
A1 Yu, Bing
A1 Bai, Yongsheng
A1 Liu, Xiaoming
YR 2019
UL http://biorxiv.org/content/early/2019/05/26/554485.abstract
AB microRNAs (miRNAs) are short non-coding RNAs that can repress the expression of protein coding messenger RNAs (mRNAs) by binding to the 3’UTR of the target. Genetic mutations such as single nucleotide variants (SNVs) in the 3’UTR of the mRNAs can disrupt this regulatory effect. In this study, we presented dbMTS, the database for miRNA target site (MTS) SNVs, which includes all potential MTS SNVs in the 3’UTR of human genome along with hundreds of functional annotations. This database can help studies easily identify putative SNVs that affect miRNA targeting and facilitate the prioritization of their functional importance. dbMTS is freely available at: https://sites.google.com/site/jpopgen/dbNSFP.