RT Journal Article
SR Electronic
T1 Gut microbiome activity contributes to individual variation in glycemic response in adults
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 641019
DO 10.1101/641019
A1 Hal Tily
A1 Ally Perlina
A1 Eric Patridge
A1 Stephanie Gline
A1 Matvey Genkin
A1 Vishakh Gopu
A1 Haely Lindau
A1 Alisson Sjue
A1 Niels Klitgord
A1 Momchilo Vuyisich
A1 Helen Messier
A1 Guruduth Banavar
YR 2019
UL http://biorxiv.org/content/early/2019/05/28/641019.abstract
AB Limiting post-meal glycemic response is an important factor in reducing the risk of chronic metabolic diseases, and contributes to significant health benefits in people with elevated levels of blood sugar. In this study, we collected gut microbiome activity (i.e., metatranscriptomic) data and measured the glycemic responses of 550 adults who consumed more than 27,000 meals from omnivore or vegetarian/gluten-free diets. We demonstrate that gut microbiome activity makes a statistically significant contribution to individual variation in glycemic response, in addition to anthropometric factors and the nutritional composition of foods. We describe a predictive model (multilevel mixed-effects regression) of variation in glycemic response among individuals ingesting the same foods. We introduce functional features aggregated from microbial activity data as candidates for association with mechanisms of glycemic control. In summary, we demonstrate for the first time that metatranscriptomic activity of the gut microbiome is correlated with glycemic response among adults.