PT  - JOURNAL ARTICLE
AU  - Nikolas Pontikos
AU  - Sharon Chua
AU  - Paul J Foster
AU  - Stephen J Tuft
AU  - Alexander C Day
AU  - UK Biobank Eye and Vision Consortium
TI  - Frequency and Distribution of Corneal Astigmatism and Keratometry Features: Methodology and Findings of the UK Biobank Study
AID  - 10.1101/654236
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 654236
4099  - http://biorxiv.org/content/early/2019/05/29/654236.short
4100  - http://biorxiv.org/content/early/2019/05/29/654236.full
AB  - Purpose To describe corneal astigmatism in the UK Biobank population, to look for associations with other biometric variables and socio-demographic factors, and to report the proportion with abnormal keratometry and irregular astigmatism suggestive of pathological corneal ectasias such as keratoconus.Methods Cross-sectional data were obtained from UK Biobank (www.ukbiobank.ac.uk/). A subsample of 107,452 participants from UK communities had undergone an enhanced ophthalmic examination including autorefractor keratometry (Tomey RC 5000, Tomey Corp., Nagoya, Japan). After quality control and applying relevant exclusions, data on corneal astigmatism on 83,751 participants was available for analysis. Potential associations were tested through univariable regression and significant parameters carried forward for multivariable analysis.Results In a univariable analysis, the characteristics significantly protective against corneal astigmatism were gender (male), older age, darker skin colour and increased alcohol intake (all p<0.001). The parameters significantly associated with increased corneal astigmatism were older age at completion of full time education, use of UV protection and lower corrected visual acuity. After inclusion in the multivariable analysis, age, gender, age at completion of full time education, corrected visual acuity and skin colour remained significant (all p<0.001). Increased corneal astigmatism was also found to be significantly associated with amblyopia or strabismus. No individuals with abnormal keratometry or irregular astigmatism were reported.Conclusions This analysis of associations with astigmatism in a large cohort of volunteers confirms previous associations including adverse associations with younger age and female gender, and identified novel associations including darker skin colour and frequency of alcohol intake. The highest risk group for corneal astigmatism were younger females of lighter skin colour, having completed full time education later, with higher logMAR corrected visual acuity. We also confirmed that corneal astigmatism is a high risk factor for amblyopia and strabismus. Finally since no cases of keratoconus were identified, this would suggest that simple keratometry indices may not be sufficient for population screening of keratoconus.