RT Journal Article
SR Electronic
T1 A slight decrease in serum albumin level is associated with rapid progression of kidney dysfunction even within the normal range: The Yuport Health Checkup Center Cohort Study
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 655563
DO 10.1101/655563
A1 Hoichi Amano
A1 Kazunobu Yoshimura
A1 Ryutaro Iijima
A1 Kaito Waki
A1 Keisei Matsumoto
A1 Hitomi Ueda
A1 Yasuko Ito
A1 Ken Miyamoto
A1 Kimihiko Akimoto
A1 Takashi Yokoo
A1 Kazuo Inoue
A1 Hiroyuki Terawaki
YR 2019
UL http://biorxiv.org/content/early/2019/05/30/655563.abstract
AB Objective A low-normal albumin level is associated with a high risk of cardiovascular disease and mortality in the general population. However, the relationship between serum albumin level and future decline of kidney function is unclear. We aimed to clarify the effect of serum albumin level on the decline of kidney function in the general population.Methods The data used were from 11,000 participants of a voluntary health checkup program between 1998 and 2006 conducted in Japan. The primary outcome for kidney function was a difference in estimated glomerular filtration rate (ΔeGFR) of ≥3 mL/min/1.73 m2/year. The association of the risk of decreased kidney function with albumin level was determined using a logistic regression analysis. We fit separate multivariable logistic regressions for serum albumin levels (g/dL) as a continuous variable and as categorical data, classified as ≤4.3 (n=2,530), 4.4– 4.6 (n=5,427), and ≥4.7 (n=3,043).Results Of 11,000 participants, 346 had a ΔeGFR/year of ≥3. As compared with the participants with albumin levels of ≥4.7 g/dL, the risk of decline in kidney function was higher not only in those with albumin levels of ≤4.3 g/dL (adjusted OR = 2,29, 95% CI: 1.65–3.18) but also in 4.4-4.6 g/dL (adjusted OR = 1.60, 95% CI: 1.20–2.14).Conclusion Decreased albumin level is an independent risk factor for rapid decline in kidney function even within the normal range.