RT Journal Article SR Electronic T1 7 Tesla MRI of the ex vivo human brain at 100 micron resolution JF bioRxiv FD Cold Spring Harbor Laboratory SP 649822 DO 10.1101/649822 A1 Brian L. Edlow A1 Azma Mareyam A1 Andreas Horn A1 Jonathan R. Polimeni A1 M. Dylan Tisdall A1 Jean Augustinack A1 Jason P. Stockmann A1 Bram R. Diamond A1 Allison Stevens A1 Lee S. Tirrell A1 Rebecca D. Folkerth A1 Lawrence L. Wald A1 Bruce Fischl A1 Andre van der Kouwe YR 2019 UL http://biorxiv.org/content/early/2019/05/31/649822.abstract AB We present an ultra-high resolution MRI dataset of an ex vivo human brain specimen. The brain specimen was donated by a 58-year-old woman who had no history of neurological disease and died of non-neurological causes. After fixation in 10% formalin, the specimen was imaged on a 7 Tesla MRI scanner at 100 µm isotropic resolution using a custom-built 31-channel receive array coil. Single-echo multi-flip Fast Low-Angle SHot (FLASH) data were acquired over 100 hours of scan time (25 hours per flip angle), allowing derivation of a T1 parameter map and synthesized FLASH volumes. This dataset provides an unprecedented view of the three-dimensional neuroanatomy of the human brain. To optimize the utility of this resource, we warped the dataset into standard stereotactic space. We now distribute the dataset in both native space and stereotactic space to the academic community via multiple platforms. We envision that this dataset will have a broad range of investigational, educational, and clinical applications that will advance understanding of human brain anatomy in health and disease.View this table: