PT  - JOURNAL ARTICLE
AU  - Alexander C. Wilson
AU  - Dorothy V. M. Bishop
TI  - Sex chromosome trisomies are not associated with atypical lateralisation for language
AID  - 10.1101/248286
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 248286
4099  - http://biorxiv.org/content/early/2018/01/15/248286.short
4100  - http://biorxiv.org/content/early/2018/01/15/248286.full
AB  - Aim Individuals with a sex chromosome trisomy (SCT) have disproportionate problems with language compared to nonverbal skills. This may result from disruption to the typical left hemisphere bias for language processing. We tested the hypothesis that SCTs would be associated with reduced left lateralisation for language.Method In a cross-sectional design, language laterality was measured during an animation description task using functional transcranial Doppler ultrasonography (fTCD). Data were available for 75 children with an SCT (26 47,XXX girls, 25 47,XXY boys, and 24 47,XYY boys; mean age was 11;4 years, SD = 3;10 years), and 132 comparison children with typical karyotypes (69 boys; mean age was 9;1 years, SD = 1;7 years).Results Lateralisation for language did not differ between the SCT and comparison groups, either in mean laterality index or relative frequency of each laterality category (left, bilateral and right). There were no differences when splitting the SCT group by trisomy. Handedness also showed no group effects.Interpretation Our data provide no evidence for disrupted lateralisation for language in SCTs. The brain basis of the cognitive phenotype in SCTs is unlikely to be a failure of the left hemisphere to specialise for language, as previously suggested.What this paper addsChildren with a sex chromosome trisomy (SCT) have typically lateralised language.This disconfirms theories linking language problems to hemispheric specialization in SCTs