RT Journal Article
SR Electronic
T1 Loss of mitochondrial SIRT4 shortens lifespan and leads to a decline in physical activity
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 248831
DO 10.1101/248831
A1 Sweta Parik
A1 Sandipan Tewary
A1 Champakali Ayyub
A1 Ullas Kolthur-Seetharam
YR 2018
UL http://biorxiv.org/content/early/2018/01/16/248831.abstract
AB Mitochondrial mechanisms and pathways have recently emerged as critical determinants of organismal aging. While nuclear sirtuins have been shown to regulate aging, whether mitochondrial sirtuins do so is still unclear. Here, we report that mitochondrial dSirt4 mediates organismal survival. We establish that absence of dSirt4 leads to reduced lifespan independent of dietary inputs. Further by assaying locomotion, a key correlate of aging, we demonstrate that dSirt4 null flies are severely physically impaired with a significant reduction in locomotion. In summary, we report for the first time that mitochondrial dSirt4 is a key determinant of longevity and its loss leads to early aging.