RT Journal Article
SR Electronic
T1 Properties of the full random effect modelling approach with missing covariates
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 656470
DO 10.1101/656470
A1 Joakim Nyberg
A1 E. Niclas Jonsson
A1 Mats O. Karlsson
A1 Jonas Häggström
A1 members of the HBGDki Community
YR 2019
UL http://biorxiv.org/content/early/2019/06/07/656470.abstract
AB Two full model approaches was compared with respect to their ability to handle missing covariate information. The reference data analysis approach was the full model method in which the covariate effects are estimated conventionally using fixed effects, and missing covariate data is imputed with the median of the non-missing covariate information. This approach was compared to a novel full model method which treats the covariate data as observed data and estimates the covariates as random effects. A consequence of this way of handling the covariates is that no covariate imputation is required and that any missingness in the covariates is handled implicitly. The comparison between the two analysis methods was based on simulated data from a model of height for age z-scores as a function of age. Data was simulated with increasing degrees of randomly missing covariate information (0-90%) and analyzed using each of the two analysis approaches. Not surprisingly, the precision in the parameter estimates from both methods decreased with increasing degrees of missing covariate information. However, while the bias in the parameter estimates increased in a similar fashion for the reference method, the full random effects approach provided unbiased estimates for all degrees of covariate missingness.