PT  - JOURNAL ARTICLE
AU  - Sami El-Boustani
AU  - Jacque P K Ip
AU  - Vincent Breton-Provencher
AU  - Hiroyuki Okuno
AU  - Haruhiko Bito
AU  - Mriganka Sur
TI  - Locally coordinated synaptic plasticity shapes cell-wide plasticity of visual cortex neurons <em>in vivo</em>
AID  - 10.1101/249706
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 249706
4099  - http://biorxiv.org/content/early/2018/01/17/249706.short
4100  - http://biorxiv.org/content/early/2018/01/17/249706.full
AB  - Plasticity of cortical responses involves activity-dependent changes at synapses, but the manner in which different forms of synaptic plasticity act together to create functional changes in neuronal responses remains unknown. Here we show that spike-timing induced receptive field plasticity of individual visual cortex neurons in vivo is anchored by increases in synaptic strength of identified spines, and is accompanied by a novel decrease in the strength of adjacent spines on a slower time scale. The locally coordinated potentiation and depression of spines involves prominent AMPA receptor redistribution via targeted expression of the immediate early gene Arc. Similar changes accompany recovery of eye-specific responses following monocular deprivation. These findings demonstrate that Hebbian strengthening of activated synapses and heterosynaptic weakening of adjacent synapses, in dendrites with heterogeneous synaptic inputs, co-operatively orchestrate cell-wide plasticity of functional neuronal responses.One Sentence Summary Arc-mediated local synaptic plasticity regulates reorganization of synaptic responses on dendritic stretches to mediate functional plasticity of neuronal responses in vivo.