PT  - JOURNAL ARTICLE
AU  - Daniel Davis
AU  - Sarah Richardson
AU  - Joanne Hornby
AU  - Helen Bowden
AU  - Katrin Hoffmann
AU  - Maryse Weston-Clarke
AU  - Fenella Green
AU  - Nishi Chaturvedi
AU  - Alun Hughes
AU  - Diana Kuh
AU  - Elizabeth Sampson
AU  - Ruth Mizoguchi
AU  - Khai Lee Cheah
AU  - Melanie Romain
AU  - Abhi Sinha
AU  - Rodric Jenkin
AU  - Carol Brayne
AU  - Alasdair MacLullich
TI  - The Delirium and Population Health Informatics Cohort study protocol: ascertaining the determinants and outcomes from delirium in a whole population
AID  - 10.1101/248559
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 248559
4099  - http://biorxiv.org/content/early/2018/01/17/248559.short
4100  - http://biorxiv.org/content/early/2018/01/17/248559.full
AB  - Background Delirium affects 25% of older inpatients and is associated with long-term cognitive impairment and future dementia. However, no population studies have systematically ascertained cognitive function before, cognitive deficits during, and cognitive impairment after delirium. Therefore, there is a need to address the following question: does delirium, and its features (including severity, duration, and presumed aetiologies), predict long-term cognitive impairment, independent of cognitive impairment at baseline?Methods The Delirium and Population Health Informatics Cohort (DELPHIC) study is an observational population-based cohort study based in the London Borough of Camden. It is recruiting 2000 individuals aged ≥70 years and prospectively following them for two years, including daily ascertainment of all inpatient episodes for delirium. Daily inpatient assessments include the Memorial Delirium Assessment Scale, the Observational Scale for Level of Arousal, and the Hierarchical Assessment of Balance and Mobility. Data on delirium aetiology is also collected. The primary outcome is the change in the modified Telephone Interview for Cognitive Status at two years.Discussion DELPHIC is the first population sample to assess older persons before, during and after hospitalisation. The cumulative incidence of delirium in the general population aged ≥70 will be described. DELPHIC offers the opportunity to quantify the impact of delirium on cognitive and functional outcomes. Overall, DELPHIC will provide a real-time public health observatory whereby information from primary, secondary, intermediate and social care can be integrated to understand how acute illness is linked to health and social care outcomes.APACHE IIAcute Physiological and Chronic Health EvaluationDELPHICDelirium and Population Health Informatics CohortDSM-IVDiagnostic and Statistical Manual, 4th editionI-AGeDInformant Assessment for Geriatric DeliriumLINKAGE-CamdenLong-term Information and Knowledge for Ageing in CamdenMDASMemorial Delirium Assessment ScaleNEWSNational Early Warning ScoreRFHRoyal Free HospitalTICS-mTelephone Interview for Cognitive Status - modifiedUCHUniversity College Hospital