RT Journal Article
SR Electronic
T1 The Delirium and Population Health Informatics Cohort study protocol: ascertaining the determinants and outcomes from delirium in a whole population
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 248559
DO 10.1101/248559
A1 Daniel Davis
A1 Sarah Richardson
A1 Joanne Hornby
A1 Helen Bowden
A1 Katrin Hoffmann
A1 Maryse Weston-Clarke
A1 Fenella Green
A1 Nishi Chaturvedi
A1 Alun Hughes
A1 Diana Kuh
A1 Elizabeth Sampson
A1 Ruth Mizoguchi
A1 Khai Lee Cheah
A1 Melanie Romain
A1 Abhi Sinha
A1 Rodric Jenkin
A1 Carol Brayne
A1 Alasdair MacLullich
YR 2018
UL http://biorxiv.org/content/early/2018/01/17/248559.abstract
AB Background Delirium affects 25% of older inpatients and is associated with long-term cognitive impairment and future dementia. However, no population studies have systematically ascertained cognitive function before, cognitive deficits during, and cognitive impairment after delirium. Therefore, there is a need to address the following question: does delirium, and its features (including severity, duration, and presumed aetiologies), predict long-term cognitive impairment, independent of cognitive impairment at baseline?Methods The Delirium and Population Health Informatics Cohort (DELPHIC) study is an observational population-based cohort study based in the London Borough of Camden. It is recruiting 2000 individuals aged ≥70 years and prospectively following them for two years, including daily ascertainment of all inpatient episodes for delirium. Daily inpatient assessments include the Memorial Delirium Assessment Scale, the Observational Scale for Level of Arousal, and the Hierarchical Assessment of Balance and Mobility. Data on delirium aetiology is also collected. The primary outcome is the change in the modified Telephone Interview for Cognitive Status at two years.Discussion DELPHIC is the first population sample to assess older persons before, during and after hospitalisation. The cumulative incidence of delirium in the general population aged ≥70 will be described. DELPHIC offers the opportunity to quantify the impact of delirium on cognitive and functional outcomes. Overall, DELPHIC will provide a real-time public health observatory whereby information from primary, secondary, intermediate and social care can be integrated to understand how acute illness is linked to health and social care outcomes.APACHE IIAcute Physiological and Chronic Health EvaluationDELPHICDelirium and Population Health Informatics CohortDSM-IVDiagnostic and Statistical Manual, 4th editionI-AGeDInformant Assessment for Geriatric DeliriumLINKAGE-CamdenLong-term Information and Knowledge for Ageing in CamdenMDASMemorial Delirium Assessment ScaleNEWSNational Early Warning ScoreRFHRoyal Free HospitalTICS-mTelephone Interview for Cognitive Status - modifiedUCHUniversity College Hospital