TY - JOUR T1 - Spatial Information in Large-Scale Neural Recordings JF - bioRxiv DO - 10.1101/002923 SP - 002923 AU - Thaddeus R. Cybulski AU - Joshua I. Glaser AU - Adam H. Marblestone AU - Bradley M. Zamft AU - Edward S. Boyden AU - George M. Church AU - Konrad P. Kording Y1 - 2014/01/01 UR - http://biorxiv.org/content/early/2014/02/21/002923.abstract N2 - A central issue in neural recording is that of distinguishing the activities of many neurons. Here, we develop a framework, based on Fisher information, to quantify how separable a neuron’s activity is from the activities of nearby neurons. We (1) apply this framework to model information flow and spatial distinguishability for several electrical and optical neural recording methods, (2) provide analytic expressions for information content, and (3) demonstrate potential applications of the approach. This method generalizes to many recording devices that resolve objects in space and thus may be useful in the design of next-generation scalable neural recording systems. ER -