RT Journal Article
SR Electronic
T1 Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 663567
DO 10.1101/663567
A1 Todd M. Everson
A1 Marta Vives-Usano
A1 Emie Seyve
A1 Andres Cardenas
A1 Marina Lacasaña
A1 Jeffrey M. Craig
A1 Corina Lesseur
A1 Emily R. Baker
A1 Nora Fernandez-Jimenez
A1 Barbara Heude
A1 Patrice Perron
A1 Beatriz Gónzalez-Alzaga
A1 Jane Halliday
A1 Maya A. Deyssenroth
A1 Margaret R. Karagas
A1 Carmen Íñiguez
A1 Luigi Bouchard
A1 Pedro Carmona-Sáez
A1 Yuk J. Loke
A1 Ke Hao
A1 Thalia Belmonte
A1 Marie A. Charles
A1 Jordi Martorell-Marugán
A1 Evelyne Muggli
A1 Jia Chen
A1 Mariana F. Fernández
A1 Jorg Tost
A1 Antonio Gómez-Martín
A1 Stephanie J. London
A1 Jordi Sunyer
A1 Carmen J. Marsit
A1 Johanna Lepeule
A1 Marie-France Hivert
A1 Mariona Bustamante
YR 2019
UL http://biorxiv.org/content/early/2019/06/11/663567.abstract
AB Maternal smoking during pregnancy (MSDP) contributes to poor birth outcomes, in part through disrupted placental functions, which may be reflected in the placental epigenome. We meta-analyzed the associations between MSDP and placental DNA methylation (DNAm) and between DNAm and birth outcomes within the Pregnancy And Childhood Epigenetics (PACE) consortium (7 studies, N=1700, 344 with any MSDP). We identified 1224 CpGs that were associated with MSDP, of which 341 associated with birth outcomes and 141 associated with gene expression. Only 6 of these CpGs were consistent with the findings from a prior meta-analysis of cord blood DNAm, demonstrating substantial tissue-specific responses to MSDP. The placental MSDP associated CpGs were enriched for growth-factor signaling, hormone activity, inflammation, and vascularization, which play important roles in placental function. We demonstrate links between placental DNAm, MSDP and poor birth outcomes, which may better inform the mechanisms through which MSDP impacts placental function and fetal growth.