RT Journal Article
SR Electronic
T1 Microstimulation of primate neocortex targeting striosomes induces negative decision-making
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 668194
DO 10.1101/668194
A1 Satoko Amemori
A1 Ken-ichi Amemori
A1 Tomoko Yoshida
A1 Georgios K. Papageorgiou
A1 Rui Xu
A1 Hideki Shimazu
A1 Robert Desimone
A1 Ann M. Graybiel
YR 2019
UL http://biorxiv.org/content/early/2019/06/12/668194.abstract
AB Affective judgment and decision-making are strongly modulated by the pregenual anterior cingulate (pACC) and caudal orbitofrontal (cOFC) cortical regions. By combining MRI-guided electrical microstimulation with viral tracing methods in non-human primates, we demonstrate that circumscribed pACC and cOFC microstimulation sites that induce negative decision-making preferentially project to striosomes in the anterior striatum. These results outline a behaviorally important circuit from pACC/cOFC to striosomes causally modulating decision-making under emotional conflict.