@article {L{\'o}pez Del Amo665620, author = {V{\'\i}ctor L{\'o}pez Del Amo and Brittany S. Leger and Kurt J. Cox and Shubhroz Gill and Alena L. Bishop and Garrett D. Scanlon and James A. Walker and Valentino M. Gantz and Amit Choudhary}, title = {Small-molecule control of super-Mendelian inheritance in gene drives}, elocation-id = {665620}, year = {2019}, doi = {10.1101/665620}, publisher = {Cold Spring Harbor Laboratory}, abstract = {By surpassing the 50\% inheritance limit of Mendel{\textquoteright}s law of independent assortment, CRISPR-based gene drives have the potential to fight vector-borne diseases or suppress crop pests. However, contemporary gene drives could spread unchecked, posing safety concerns that limit their use in both laboratory and field settings. Current technologies also lack chemical control strategies, which could be applied in the field for dose, spatial and temporal control of gene drives. We describe in Drosophila the first gene-drive system controlled by an engineered Cas9 and a synthetic, orally-available small molecule. Graphical Abstract}, URL = {https://www.biorxiv.org/content/early/2019/06/14/665620}, eprint = {https://www.biorxiv.org/content/early/2019/06/14/665620.full.pdf}, journal = {bioRxiv} }