PT - JOURNAL ARTICLE AU - Víctor López Del Amo AU - Brittany S. Leger AU - Kurt J. Cox AU - Shubhroz Gill AU - Alena L. Bishop AU - Garrett D. Scanlon AU - James A. Walker AU - Valentino M. Gantz AU - Amit Choudhary TI - Small-molecule control of super-Mendelian inheritance in gene drives AID - 10.1101/665620 DP - 2019 Jan 01 TA - bioRxiv PG - 665620 4099 - http://biorxiv.org/content/early/2019/06/14/665620.short 4100 - http://biorxiv.org/content/early/2019/06/14/665620.full AB - By surpassing the 50% inheritance limit of Mendel’s law of independent assortment, CRISPR-based gene drives have the potential to fight vector-borne diseases or suppress crop pests. However, contemporary gene drives could spread unchecked, posing safety concerns that limit their use in both laboratory and field settings. Current technologies also lack chemical control strategies, which could be applied in the field for dose, spatial and temporal control of gene drives. We describe in Drosophila the first gene-drive system controlled by an engineered Cas9 and a synthetic, orally-available small molecule. Graphical Abstract