RT Journal Article SR Electronic T1 Small-molecule control of super-Mendelian inheritance in gene drives JF bioRxiv FD Cold Spring Harbor Laboratory SP 665620 DO 10.1101/665620 A1 Víctor López Del Amo A1 Brittany S. Leger A1 Kurt J. Cox A1 Shubhroz Gill A1 Alena L. Bishop A1 Garrett D. Scanlon A1 James A. Walker A1 Valentino M. Gantz A1 Amit Choudhary YR 2019 UL http://biorxiv.org/content/early/2019/06/14/665620.abstract AB By surpassing the 50% inheritance limit of Mendel’s law of independent assortment, CRISPR-based gene drives have the potential to fight vector-borne diseases or suppress crop pests. However, contemporary gene drives could spread unchecked, posing safety concerns that limit their use in both laboratory and field settings. Current technologies also lack chemical control strategies, which could be applied in the field for dose, spatial and temporal control of gene drives. We describe in Drosophila the first gene-drive system controlled by an engineered Cas9 and a synthetic, orally-available small molecule. Graphical Abstract