RT Journal Article
SR Electronic
T1 Distinct roles of parvalbumin and somatostatin interneurons in the synchronization of spike-times in the neocortex
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 671743
DO 10.1101/671743
A1 Jang, Hyun Jae
A1 Chung, Hyowon
A1 Rowland, James M.
A1 Richards, Blake A.
A1 Kohl, Michael M.
A1 Kwag, Jeehyun
YR 2019
UL http://biorxiv.org/content/early/2019/06/15/671743.abstract
AB Synchronization of precise spike-times across multiple neurons carries information about sensory stimuli. Inhibitory interneurons are suggested to promote this synchronization, but it is unclear whether distinct interneuron subtypes provide different contributions. To test this, we examined single-unit recordings from barrel cortex in vivo and used optogenetics to determine the contribution of two classes of inhibitory interneurons: parvalbumin (PV)- and somatostatin (SST)-positive interneurons to spike-timing synchronization across cortical layers. We found that PV interneurons preferentially promote the synchronization of spike-times when instantaneous firing-rates are low (<12 Hz), whereas SST interneurons preferentially promote the synchronization of spike-times when instantaneous firing-rates are high (>12 Hz). Furthermore, using a computational model, we demonstrate that these effects can be explained by PV and SST interneurons having preferential contribution to feedforward and feedback inhibition, respectively. Our findings demonstrate that distinct subtypes of inhibitory interneurons have frequency-selective roles in spatio-temporal synchronization of precise spike-times.