RT Journal Article
SR Electronic
T1 A comprehensive manually-curated Compendium of Bovine Transcription Factors
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 254011
DO 10.1101/254011
A1 Marcela M de Souza
A1 Juan M Vaquerizas
A1 Adhemar Zerlotini
A1 Ludwig Geistlinger
A1 Benjamín Hernández-Rodríguez
A1 Polyana C Tizioto
A1 Jeremy F Taylor
A1 Marina IP Rocha
A1 Wellison JS Diniz
A1 Luiz L Coutinho
A1 Luciana CA Regitano
YR 2018
UL http://biorxiv.org/content/early/2018/01/27/254011.abstract
AB Transcription factors (TFs) are pivotal regulatory proteins that control gene expression in a context-dependent and tissue-specific manner. In contrast to human, where comprehensive curated TF collections exist, bovine TFs are only rudimentary recorded and characterized. In this article, we present a manually-curated compendium of 865 sequence-specific DNA-binding bovines TFs, which we analyzed for domain family distribution, evolutionary conservation, and tissue-specific expression. In addition, we provide a list of putative transcription cofactors derived from known interactions with the identified TFs. Since there is a general lack of knowledge concerning the regulation of gene expression in cattle, the curated list of TF should provide a basis for an improved comprehension of regulatory mechanisms that are specific to the species.