RT Journal Article
SR Electronic
T1 Potential Autoimmune Association between Benign Paroxysmal Positional Vertigo and Immune-mediated Skin Conditions: Population-based Cohort Study
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 676973
DO 10.1101/676973
A1 Hyung Jin Hahn
A1 Sang Gyu Kwak
A1 Dong-Kyu Kim
A1 Jong-Yeup Kim
YR 2019
UL http://biorxiv.org/content/early/2019/06/19/676973.abstract
AB Background Benign paroxysmal positional vertigo (BPPV), an idiopathic disorder of sudden sensorineural hearing loss and vertigo, shares many similarities with two common skin conditions, atopic dermatitis (AD) and vitiligo. Recent studies have suggested that BPPV may be related to or triggered by autoimmune conditions, notably hypothyroidism and giant cell arteritis (GCA).Objective These evidences prompted the authors to entertain the possibility of immunological bridge between BPPV and the two skin conditions. The authors have tested this hypothesis with population-based cohort from the National Health Insurance Service Database of Korea.Methods A cohort of 1.1 million patients was extracted from the DB. Using χ2 tests, prevalence of the two skin disorders in terms of BPPV status was analysed.Results In AD patients, the prevalence of BPPV was 30% lower, while there was no statistically significant relationship between BPPV prevalence and vitiligo. The relationship between vitiligo and BPPV was significant in younger subgroup only. Socio-economic subgroup analysis revealed the observed patterns are primarily a middle-upper class phenomenon.Limitations Uncertainty regarding temporal sequence of onset, and lack of detail on disease severity and subtype might have kept the authors from drawing more refined conclusion.Conclusion AD and vitiligo might be linked to BPPV through the action of certain components of cellular immunity, but follow-up studies based on large population cohort would be needed to add more substance to our findings.