RT Journal Article
SR Electronic
T1 Altered White Matter Microstructural Organization in Post-Traumatic Stress Disorder across 3,049 Adults: Results from the PGC-ENIGMA PTSD Consortium
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 677153
DO 10.1101/677153
A1 Emily L Dennis
A1 Seth G Disner
A1 Negar Fani
A1 Lauren E Salminen
A1 Mark Logue
A1 Emily K Clarke
A1 Courtney C Haswell
A1 Christopher L Averill
A1 Lee A Baugh
A1 Jessica Bomyea
A1 Steven E Bruce
A1 Jiook Cha
A1 Kyle Choi
A1 Nicholas D Davenport
A1 Maria Densmore
A1 Stefan du Plessis
A1 Gina L Forster
A1 Jessie L Frijling
A1 Atilla Gönenc
A1 Staci Gruber
A1 Daniel W Grupe
A1 Jeffrey P Guenette
A1 Jasmeet Hayes
A1 David Hofmann
A1 Jonathan Ipser
A1 Tanja Jovanovic
A1 Sinead Kelly
A1 Mitzy Kennis
A1 Philipp Kinzel
A1 Saskia BJ Koch
A1 Inga Koerte
A1 Sheri Koopowitz
A1 Mayuresh Korgaonkar
A1 John Krystal
A1 Lauren AM Lebois
A1 Gen Li
A1 Vincent A Magnotta
A1 Antje Manthey
A1 Geoffrey J May
A1 Deleene S Menefee
A1 Laura Nawijn
A1 Steven M Nelson
A1 Richard WJ Neufeld
A1 Jack B Nitschke
A1 Daniel O’Doherty
A1 Matthew Peverill
A1 Kerry Ressler
A1 Annerine Roos
A1 Margaret A Sheridan
A1 Anika Sierk
A1 Alan Simmons
A1 Raluca M Simons
A1 Jeffrey S Simons
A1 Jennifer Stevens
A1 Benjamin Suarez-Jimenez
A1 Danielle R Sullivan
A1 Jean Théberge
A1 Jana K Tran
A1 Leigh van den Heuvel
A1 Steven JA van der Werff
A1 Sanne JH van Rooij
A1 Mirjam van Zuiden
A1 Carmen Velez
A1 Mieke Verfaellie
A1 Robert RJM Vermeiren
A1 Benjamin SC Wade
A1 Tor Wager
A1 Henrik Walter
A1 Sherry Winternitz
A1 Jonathan Wolff
A1 Gerald York
A1 Ye Zhu
A1 Xi Zhu
A1 Chadi G Abdallah
A1 Richard Bryant
A1 Judith K Daniels
A1 Richard J Davidson
A1 Kelene A Fercho
A1 Carol Franz
A1 Elbert Geuze
A1 Evan M Gordon
A1 Milissa L Kaufman
A1 William Kremen
A1 Jim Lagopoulos
A1 Ruth A Lanius
A1 Michael J Lyons
A1 Stephen R McCauley
A1 Regina McGlinchey
A1 Katie A McLaughlin
A1 William Milberg
A1 Yuval Neria
A1 Miranda Olff
A1 Soraya Seedat
A1 Martha Shenton
A1 Scott R Sponheim
A1 Dan J Stein
A1 Murray B Stein
A1 Thomas Straube
A1 David F Tate
A1 Nic JA van der Wee
A1 Dick J Veltman
A1 Li Wang
A1 Elisabeth A Wilde
A1 Paul M Thompson
A1 Peter Kochunov
A1 Neda Jahanshad
A1 Rajendra A Morey
YR 2019
UL http://biorxiv.org/content/early/2019/06/20/677153.abstract
AB A growing number of studies have examined alterations in white matter organization in people with posttraumatic stress disorder (PTSD) using diffusion MRI (dMRI), but the results have been mixed, which may be partially due to relatively small sample sizes among studies. Altered structural connectivity may be both a neurobiological vulnerability for, and a result of, PTSD. In an effort to find reliable effects, we present a multi-cohort analysis of dMRI metrics across 3,049 individuals from 28 cohorts currently participating in the PGC-ENIGMA PTSD working group (a joint partnership between the Psychiatric Genomics Consortium and the Enhancing NeuroImaging Genetics through Meta-Analysis consortium). Comparing regional white matter metrics across the full brain in 1,446 individuals with PTSD and 1,603 controls (2152 males/897 females) between ages 18-83, 92% of whom were trauma-exposed, we report associations between PTSD and disrupted white matter organization measured by lower fractional anisotropy (FA) in the tapetum region of the corpus callosum (Cohen’s d=−0.12, p=0.0021). The tapetum connects the left and right hippocampus, structures for which structure and function have been consistently implicated in PTSD. Results remained significant/similar after accounting for the effects of multiple potentially confounding variables: childhood trauma exposure, comorbid depression, history of traumatic brain injury, current alcohol abuse or dependence, and current use of psychotropic medications. Our results show that PTSD may be associated with alterations in the broader hippocampal network.