PT - JOURNAL ARTICLE AU - Claudino, Leonardo AU - Hussain, Sara J AU - Buch, Ethan R AU - Cohen, Leonardo G TI - Offline coil position denoising enhances detection of TMS effects AID - 10.1101/256081 DP - 2018 Jan 01 TA - bioRxiv PG - 256081 4099 - http://biorxiv.org/content/early/2018/01/30/256081.short 4100 - http://biorxiv.org/content/early/2018/01/30/256081.full AB - OBJECTIVE: Transcranial magnetic stimulation (TMS) is extensively used in basic and clinical neuroscience. Previous work has shown substantial residual variability in TMS effects even despite use of on-line visual feedback monitoring of coil position. Here, we aimed to evaluate if off-line modeling of coil position and orientation deviations can enhance detection of TMS effects. METHODS: Retrospective modeling was used to denoise the impact of common coil position and rotation deviations during TMS experimental sessions on motor evoked potentials (MEP) to single pulse TMS. RESULTS: Offline denoising led to a 26.19% improvement in the signal to noise ratio (SNR) of corticospinal excitability measurements. CONCLUSIONS: Offline modeling enhanced detection of TMS effects by removing variability introduced by coil deviations. SIGNIFICANCE: This approach could allow more accurate determination of TMS effects in cognitive and interventional neuroscience.HIGHLIGHTSCoil deviations impact TMS effects despite use of on-line neuronavigation feedback.Offline denoising of coil deviation impacts on TMS effects reduced variability.Offline denoising also significantly improved overall SNR of TMS effects.