PT  - JOURNAL ARTICLE
AU  - Leonardo Claudino
AU  - Sara J Hussain
AU  - Ethan R Buch
AU  - Leonardo G Cohen
TI  - Offline coil position denoising enhances detection of TMS effects
AID  - 10.1101/256081
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 256081
4099  - http://biorxiv.org/content/early/2018/01/30/256081.short
4100  - http://biorxiv.org/content/early/2018/01/30/256081.full
AB  - OBJECTIVE: Transcranial magnetic stimulation (TMS) is extensively used in basic and clinical neuroscience. Previous work has shown substantial residual variability in TMS effects even despite use of on-line visual feedback monitoring of coil position. Here, we aimed to evaluate if off-line modeling of coil position and orientation deviations can enhance detection of TMS effects. METHODS: Retrospective modeling was used to denoise the impact of common coil position and rotation deviations during TMS experimental sessions on motor evoked potentials (MEP) to single pulse TMS. RESULTS: Offline denoising led to a 26.19% improvement in the signal to noise ratio (SNR) of corticospinal excitability measurements. CONCLUSIONS: Offline modeling enhanced detection of TMS effects by removing variability introduced by coil deviations. SIGNIFICANCE: This approach could allow more accurate determination of TMS effects in cognitive and interventional neuroscience.HIGHLIGHTSCoil deviations impact TMS effects despite use of on-line neuronavigation feedback.Offline denoising of coil deviation impacts on TMS effects reduced variability.Offline denoising also significantly improved overall SNR of TMS effects.