RT Journal Article
SR Electronic
T1 EpiSort: Enumeration of cell types using targeted bisulfite sequencing
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 677211
DO 10.1101/677211
A1 Aran, Dvir
A1 Dover, Ron S.
A1 Lundy, Karen E.
A1 Leipold, Michael D.
A1 Xuhuai, Ji
A1 McDevitt, Shana L.
A1 Davis, Mark M.
A1 Butte, Atul J.
YR 2019
UL http://biorxiv.org/content/early/2019/06/21/677211.abstract
AB The cellular composition of tumors is now recognized as an essential phenotype, with implications to diagnostic, progression and therapy efficacy. A tool for accurate profiling of the tumor microenvironment is lacking, as single-cell methods and computational approaches are not applicable or suffer from low accuracy. Here we present EpiSort, a novel strategy based on targeted bisulfite sequencing, which allows the accurate enumeration of 23 cell types and may be applicable to cancer studies.