RT Journal Article
SR Electronic
T1 Guillain-Barre syndrome outbreak in Peru: Association with polymorphisms in <em>IL-17, ICAM-1</em> and <em>CD1</em>
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 667154
DO 10.1101/667154
A1 Luis Jaramillo-Valverde
A1 Kelly S Levano
A1 Isolina Villanueva
A1 Meylin Hidalgo
A1 Marco Cornejo
A1 Pilar Mazzetti
A1 Mario Cornejo-Olivas
A1 Cesar Sanchez
A1 Julio A Poterico
A1 Julio Valdivia-Silva
A1 Heinner Guio
YR 2019
UL http://biorxiv.org/content/early/2019/06/21/667154.abstract
AB Guillain-Barre Syndrome (GBS) is considered a complex disorder with significant environmental effect and genetic susceptibility. Genetic polymorphisms in CD1E, CD1A, IL-17 and/or ICAM-1 genes had been proposed as susceptibility genetic variants for GBS mainly in Caucasian population. This study explores the association between selected polymorphisms in these genes and GBS susceptibility in confirmed GBS cases reported in mestizo population from northern Peru during the most recent GBS outbreak of May 2018. A total of 9 non-related cases and 11 controls were sequenced for the polymorphic regions of CD1A, CD1E, IL-17 and ICAM-1 genes. We found a significant protective association between heterozygous GA genotype in ICAM-1 gene (241Gly / Arg) and GBS (p &lt;0.047). IL-17 was monomorphic in both controls and patients. No significant differences were found in the frequency of SNPs in CD1A and CD1E between the group with GBS patients and healthy controls. Further studies with larger sample size will be required to validate these findings.