RT Journal Article
SR Electronic
T1 Unbiased Assessment of H-STS cells as high-fidelity models for gastro-enteropancreatic neuroendocrine tumor drug mechanism of action analysis
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 677435
DO 10.1101/677435
A1 Mariano J. Alvarez
A1 Pengrong Yan
A1 Mary L. Alpaugh
A1 Michaela Bowden
A1 Ewa Sicinska
A1 Chensheng W. Zhou
A1 Charles Karan
A1 Ronald B. Realubit
A1 Prabhjot S. Mundi
A1 Adina Grunn
A1 Dirk Jäger
A1 John A. Chabot
A1 Antonio T. Fojo
A1 Paul E. Oberstein
A1 Hanina Hibshoosh
A1 Jeffrey W. Milsom
A1 Matthew H. Kulke
A1 Massimo Loda
A1 Gabriela Chiosis
A1 Diane L. Reidy-Lagunes
A1 Andrea Califano
YR 2019
UL http://biorxiv.org/content/early/2019/06/23/677435.abstract
AB Quantitative metrics to objectively assess the fidelity of cancer models, such as cell lines, organoids, or patient-derived xenografts (PDXs), remain elusive, with histological criteria or the presence of specific mutations often used as driving principles. We show that molecular criteria, based on the regulatory proteins responsible for maintaining transcriptional cell state and its regulatory network, are effective in identifying models that can recapitulate drug mechanism of action and drug sensitivity, independent of histological consideration.