RT Journal Article
SR Electronic
T1 Potential antigenic mismatch of the H3N2 component of the 2019 Southern Hemisphere influenza vaccine
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 681734
DO 10.1101/681734
A1 Sigrid Gouma
A1 Madison Weirick
A1 Scott E. Hensley
YR 2019
UL http://biorxiv.org/content/early/2019/06/24/681734.abstract
AB Here, we find that the egg-adapted H3N2 component of the 2019 Southern Hemisphere influenza vaccine elicits an antibody response in ferrets that is highly focused on antigenic site A of hemagglutinin. This is potentially problematic since most H3N2 viruses currently circulating in the Southern Hemisphere possess antigenic site A substitutions.