RT Journal Article
SR Electronic
T1 Sleepless and Desynchronized: Impaired Inter Trial Phase Coherence of Steady-State Potentials Following Sleep Deprivation
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 471730
DO 10.1101/471730
A1 M Eidelman-Rothman
A1 E Ben-Simon
A1 D Freche
A1 A Keil
A1 T Hendler
A1 N Levit-Binnun
YR 2019
UL http://biorxiv.org/content/early/2019/06/25/471730.abstract
AB Sleep loss has detrimental effects on cognitive and emotional functioning. These impairments have been associated with alterations in EEG measures of power spectrum and event-related potentials, however the impact of sleep loss on inter trial phase coherence (ITPC), a measure of phase consistency over experimental trials, remains mostly unknown. ITPC is thought to reflect the ability of the neural response to temporally synchronize with relevant events, thus optimizing information processing.In the current study we investigated the effects of sleep deprivation on information processing by evaluating the phase consistency of steady-state visual evoked potentials (ssVEPs) as well as amplitude-based measures of ssVEP, obtained from a group of 18 healthy individuals following 24 hours of total sleep deprivation and after a night of habitual sleep. An ssVEP task was utilized, which included the presentation of dots flickering at 7.5 Hz, along with a cognitive-emotional task. Our results show that ITPC is significantly reduced under sleep deprivation relative to habitual sleep. Interestingly, decreased ITPC under sleep deprivation was associated with decreased behavioral performance in the psychomotor vigilance task (PVT), a validate measure of reduced vigilance following lack of sleep.The results suggest that the capability of the brain to synchronize with rhythmic stimuli is disrupted without sleep. Thus, decreased ITPC may represent an objective and mechanistic measure of sleep loss, allowing future work to study the relation between brain-world synchrony and the specific functional impairments associated with sleep deprivation.