PT  - JOURNAL ARTICLE
AU  - Meret Branscheidt
AU  - Naveed Ejaz
AU  - Jing Xu
AU  - Mario Widmer
AU  - Michelle D. Harran
AU  - Juan Camillo Cortés
AU  - Tomoko Kitago
AU  - Pablo Celnik
AU  - Carlos Hernandez-Castillo
AU  - Jörn Diedrichsen
AU  - Andreas Luft
AU  - John W. Krakauer
TI  - No evidence for motor recovery-related cortical reorganization after stroke using resting-state fMRI
AID  - 10.1101/681320
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 681320
4099  - http://biorxiv.org/content/early/2019/06/26/681320.short
4100  - http://biorxiv.org/content/early/2019/06/26/681320.full
AB  - Cortical reorganization has been suggested as mechanism for recovery after stroke. It has been proposed that a form of cortical reorganization (changes in functional connectivity between brain areas) can be assessed with resting-state fMRI. Here we report the largest longitudinal data-set in terms of overall sessions in 19 patients with subcortical stroke and 11 controls. Patients were imaged up to 5 times over one year. We found no evidence for post-stroke cortical reorganization despite substantial behavioral recovery. These results could be construed as questioning the value of resting-state imaging. Here we argue instead that they are consistent with other emerging reasons to challenge the idea of motor recovery-related cortical reorganization post-stroke when conceived as changes in connectivity between cortical areas.