RT Journal Article
SR Electronic
T1 Neural correlates of exceptional memory ability in SuperAgers: A multimodal approach using FDG-PET, PIB-PET, and MRI
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 666438
DO 10.1101/666438
A1 Wyllians Vendramini Borelli
A1 Eduardo Leal-Conceição
A1 Michele Alberton Andrade
A1 Nathalia Bianchini Esper
A1 Paula Kopschina Feltes
A1 Ricardo Bernardi Soder
A1 Cristina Sebastião Matushita
A1 Louise Mross Hartmann
A1 Graciane Radaelli
A1 Lucas Porcello Schilling
A1 Cristina Moriguchi-Jeckel
A1 Ana Maria Marques da Silva
A1 Mirna Wetters Portuguez
A1 Alexandre Rosa Franco
A1 Jaderson Costa da Costa
YR 2019
UL http://biorxiv.org/content/early/2019/06/26/666438.abstract
AB Individuals at 80 years of age or above with exceptional memory are considered SuperAgers (SA). A multimodal brain analysis of SA may provide biomarkers of successful cognitive aging. Herein, a molecular (PET-FDG, PET-PIB), functional (fMRI) and structural analysis (MRI) of SA was conducted. Ten SA, ten age-matched older adults (C80) and ten cognitively normal middle-aged adults underwent cognitive testing and neuroimaging examinations. The relationship between cognitive scores and cingulate areas and hippocampus were examined. The SA group showed increased FDG SUVr in the left subgenual Anterior Cingulate Cortex (sACC, p<0.005) as compared to that in the C80 group. Amyloid deposition was similar between SA and C80 in the described regions or overall areas (p>0.05). The SA group also presented decreased connectivity between left sACC and posterior cingulate (p<0.005) as compared to that of C80 group. These results support the key role of ACC in SA, even in the presence of amyloid deposition. It also suggests that sACC can be used as a potential memory biomarker in older adults.Abbreviations BCa – Bias corrected accelerated: SA – SuperAgers: C50 – Middle-aged controls: C80 – Age-matched controls