PT  - JOURNAL ARTICLE
AU  - Linda Ongaro
AU  - Marilia O. Scliar
AU  - Rodrigo Flores
AU  - Alessandro Raveane
AU  - Davide Marnetto
AU  - Stefania Sarno
AU  - Guido A. Gnecchi-Ruscone
AU  - Marta Alarcon-Riquelme
AU  - Etienne Patin
AU  - Pongsakorn Wangkumhang
AU  - Garrett Hellenthal
AU  - Miguel Gonzalez-Santos
AU  - Roy J. King
AU  - Anastasia Kouvatsi
AU  - Oleg Balanovsky
AU  - Elena Balanovska
AU  - Lubov Atramentova
AU  - Shahlo Turdikulova
AU  - Sarabjit Mastana
AU  - Damir Marjanovic
AU  - Lejla Kovacevic
AU  - Andreja Leskovac
AU  - Maria F. Lima-Costa
AU  - Alexandre C. Pereira
AU  - Mauricio L. Barreto
AU  - Bernardo L. Horta
AU  - Nédio Mabunda
AU  - Celia A. May
AU  - Andres Moreno-Estrada
AU  - Alessandro Achilli
AU  - Anna Olivieri
AU  - Ornella Semino
AU  - Kristiina Tambets
AU  - Toomas Kivisild
AU  - Donata Luiselli
AU  - Antonio Torroni
AU  - Cristian Capelli
AU  - Eduardo Tarazona-Santos
AU  - Mait Metspalu
AU  - Luca Pagani
AU  - Francesco Montinaro
TI  - The genomic impact of European colonization of the Americas
AID  - 10.1101/676437
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 676437
4099  - http://biorxiv.org/content/early/2019/06/28/676437.short
4100  - http://biorxiv.org/content/early/2019/06/28/676437.full
AB  - The human genetic diversity of the Americas has been shaped by several events of gene flow that have continued since the Colonial Era and the Atlantic slave trade. Moreover, multiple waves of migration followed by local admixture occurred in the last two centuries, the impact of which has been largely unexplored.Here we compiled a genome-wide dataset of ∼12,000 individuals from twelve American countries and ∼6,000 individuals from worldwide populations and applied haplotype-based methods to investigate how historical movements from outside the New World affected i) the genetic structure, ii) the admixture profile, iii) the demographic history and iv) sex-biased gene-flow dynamics, of the Americas.We revealed a high degree of complexity underlying the genetic contribution of European and African populations in North and South America, from both geographic and temporal perspectives, identifying previously unreported sources related to Italy, the Middle East and to specific regions of Africa.