@article {Boersch-Supan259705, author = {Philipp H. Boersch-Supan and Leah R. Johnson}, title = {A tutorial on Bayesian parameter inference for dynamic energy budget models}, elocation-id = {259705}, year = {2018}, doi = {10.1101/259705}, publisher = {Cold Spring Harbor Laboratory}, abstract = {Mechanistic representations of individual life-history trajectories are powerful tools for the prediction of organismal growth, reproduction and survival under novel environmental conditions. Dynamic energy budget (DEB) theory provides compact models to describe the acquisition and allocation of organisms over their full life cycle of bioenergetics. However, estimating DEB model parameters, and their associated uncertainties and covariances, is not trivial. Bayesian inference provides a coherent way to estimate parameter uncertainty, and propagate it through the model, while also making use of prior information to constrain the parameter space. We outline a Bayesian inference approach for energy budget models and provide two case studies {\textendash} based on a simplified DEBkiss model, and the standard DEB model {\textendash} detailing the implementation of such inference procedures using the open-source software package deBInfer. We demonstrate how DEB and DEBkiss parameters can be estimated in a Bayesian framework, but our results also highlight the difficulty of identifying DEB model parameters which serves as a reminder that fitting these models requires statistical caution.}, URL = {https://www.biorxiv.org/content/early/2018/02/05/259705}, eprint = {https://www.biorxiv.org/content/early/2018/02/05/259705.full.pdf}, journal = {bioRxiv} }