RT Journal Article
SR Electronic
T1 Adaptive and Wireless Recordings of Electrophysiological Signals during Concurrent Magnetic Resonance Imaging
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 259762
DO 10.1101/259762
A1 Ranajay Mandal
A1 Nishant Babaria
A1 Jiayue Cao
A1 Zhongming Liu
YR 2018
UL http://biorxiv.org/content/early/2018/02/05/259762.abstract
AB Strong electromagnetic fields during functional magnetic resonance imaging (fMRI) presents a challenging environment for any concurrent electrophysiological recording. Here, we present a miniaturized, wireless platform – “MR-Link” (Multimodal Recording Link) that provides a hardware solution for simultaneous electrophysiological and fMRI signal acquisition. The device detects changes in the electromagnetic field during fMRI and synchronizes amplification and sampling of electrophysiological signals to minimize effects of gradient and RF artifacts. It wirelessly transmits the recorded data at a frequency detectable by the MR-receiver coil. The transmitted data is readily separable from MRI in the frequency domain. To demonstrate its efficacy, we used this device to record electrocardiograms and somatosensory evoked potential without artifacts from concurrent fMRI scans, or compromising imaging quality. The compact recording device (20 mm dia., 2gms) placed within the MR-bore minimized movement artifacts and achieved microsecond-level synchronization with fMRI data. MR-Link offers an inexpensive system to eliminate the need for amplifiers with high dynamic range or sampling rate, high-power sampling, additional storage or synchronization hardware to connect with the MR-scanner. This device is expected to enable easier and a broader range of applications of simultaneous fMRI and electrophysiology in animals and humans.