RT Journal Article
SR Electronic
T1 ChIP-BIT2: a software tool to detect weak binding events using a Bayesian integration approach
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 260869
DO 10.1101/260869
A1 Xi Chen
A1 Xu Shi
A1 Leena Hilakivi-Clarke
A1 Robert Clarke
A1 Tian-Li Wang
A1 Jianhua Xuan
YR 2018
UL http://biorxiv.org/content/early/2018/02/07/260869.abstract
AB Transcription factor binding events play important functional roles in gene regulation. It is, however, a challenging task to detect weak binding events since the ambiguity in differentiation of weak binding signals from background signals. We present a software package, ChIP-BIT2, to identify weak binding events using a Bayesian integration approach. By integrating signals from sample and input ChIP-seq data, ChIP-BIT2 can detect both strong and weak binding events at gene promoter, enhancer or the whole genome effectively. The ChIP-BIT2 package has been extensively tested on ChIP-seq data, demonstrating its wide applicability in ChIP-seq data analysis.Availability and Implementation The ChIP-BIT2 package is available at http://sourceforge.net/projects/chipbitc/.