RT Journal Article
SR Electronic
T1 Printable microscale interfaces for long-term peripheral nerve mapping and precision control
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 688218
DO 10.1101/688218
A1 Timothy M. Otchy
A1 Christos Michas
A1 Blaire Lee
A1 Krithi Gopalan
A1 Jeremy Gleick
A1 Dawit Semu
A1 Louis Darkwa
A1 Bradley J. Holinski
A1 Daniel J. Chew
A1 Alice E. White
A1 Timothy J. Gardner
YR 2019
UL http://biorxiv.org/content/early/2019/07/02/688218.abstract
AB The nascent field of bioelectronic medicine seeks to decode and modulate peripheral nervous system signals to obtain therapeutic control of targeted end organs and effectors. Current approaches rely heavily on electrode-based devices, but size scalability, material and microfabrication challenges, limited surgical accessibility, and the biomechanically dynamic implantation environment are significant impediments to developing and deploying advanced peripheral interfacing technologies. Here, we present a microscale implantable device – the nanoclip – for chronic interfacing with fine peripheral nerves in small animal models that begins to meet these constraints. We demonstrate the capability to make stable, high-resolution recordings of behaviorally-linked nerve activity over multi-week timescales. In addition, we show that multi-channel, current-steering-based stimulation can achieve a high degree of functionally-relevant modulatory specificity within the small scale of the device. These results highlight the potential of new microscale design and fabrication techniques for the realization of viable implantable devices for long-term peripheral interfacing.