PT - JOURNAL ARTICLE AU - Simon Dellicour AU - Guy Baele AU - Gytis Dudas AU - Nuno R. Faria AU - Oliver G. Pybus AU - Marc A. Suchard AU - Andrew Rambaut AU - Philippe Lemey TI - Phylodynamic assessment of intervention strategies for the West African Ebola virus outbreak AID - 10.1101/163691 DP - 2018 Jan 01 TA - bioRxiv PG - 163691 4099 - http://biorxiv.org/content/early/2018/02/08/163691.short 4100 - http://biorxiv.org/content/early/2018/02/08/163691.full AB - This preprint has been reviewed and recommended by Peer Community In Evolutionary Biology (http://dx.doi.org/10.24072/pci.evolbiol.100046). The recent Ebola virus (EBOV) outbreak in West Africa witnessed considerable efforts to obtain viral genomic data as the epidemic was unfolding. If such data can be deployed in real-time, molecular epidemiological investigations could play a role in complementing contact tracing undertaken by public health agencies. Analysing the EBOV genomes accumulated to date can also deliver insights into epidemic dynamics. Such analyses have been shown that metapopulation dynamics were critical for EBOV dispersal between rural and urban areas during the epidemic, but the implications for specific intervention scenarios remain unclear. Here, we address this issue using a collection of phylodynamic approaches. We show that long-distance dispersal events (between administrative areas >250 km apart) were not crucial for epidemic expansion and that preventing viral lineage movement to any given administrative area would, in most cases, have had little impact. However, urban areas – specifically those encompassing the three capital cities and their suburbs – were critical in attracting and further disseminating the virus: preventing viral lineage movement to all three simultaneously would have contained epidemic size by two-thirds. Using continuous phylogeographic reconstructions we estimate a distance kernel for EBOV spread and reveal considerable heterogeneity in dispersal velocity through time. We also show that announcements of border closures were followed by a significant but transient effect on international virus dispersal. By quantifying the hypothetical impact of different intervention strategies as well as the impact of barriers on dispersal frequency, our study illustrates how phylodynamic analyses can help to address specific epidemiological and outbreak control questions.