RT Journal Article
SR Electronic
T1 The role of lipoprotein subfractions in coronary artery disease: A Mendelian randomization study
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 691089
DO 10.1101/691089
A1 Qingyuan Zhao
A1 Jingshu Wang
A1 Zhen Miao
A1 Nancy Zhang
A1 Sean Hennessy
A1 Dylan S Small
A1 Daniel J Rader
YR 2019
UL http://biorxiv.org/content/early/2019/07/03/691089.abstract
AB Lipoprotein subfractions and particle sizes are increasingly used in observational studies to predict the risk of cardiovascular diseases. However, the causal role of the different subfractions remain largely uncertain because the conventional study designs are subject to unmeasured confounding. We used Mendelian randomization and public GWAS summary data to estimate the effect of 82 lipoprotein subfraction and particle size traits on the occurrence of coronary artery disease and myocardial infarction. We found that, unlike LDL and VLDL subfractions, HDL subfraction traits appear to have heterogeneous effects on coronary artery disease according to particle size. The concentration of medium HDL particles may have a protective effect on coronary artery disease that is independent of traditional lipid factors.