TY - JOUR T1 - Linking transcriptome and chromatin accessibility in nanoliter droplets for single-cell sequencing JF - bioRxiv DO - 10.1101/692608 SP - 692608 AU - Song Chen AU - Blue B Lake AU - Kun Zhang Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/07/04/692608.abstract N2 - Linked profiling of transcriptome and chromatin accessibility from single cells can provide unprecedented insights into cellular status. Here we developed a droplet-based Single-Nucleus chromatin Accessibility and mRNA Expression sequencing (SNARE-seq) assay, that we used to profile neonatal and adult mouse cerebral cortices. To demonstrate the strength of single-cell dual-omics profiling, we reconstructed transcriptome and epigenetic landscapes of cell types, uncovered lineage-specific accessible sites, and connected dynamics of promoter accessibility with transcription during neurogenesis. ER -