RT Journal Article
SR Electronic
T1 Neurology-related protein biomarkers are associated with general fluid cognitive ability and brain volume in older age
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 692459
DO 10.1101/692459
A1 Sarah E. Harris
A1 Simon R. Cox
A1 Steven Bell
A1 Riccardo E. Marioni
A1 Bram P Prins
A1 Alison Pattie
A1 Janie Corley
A1 Susana Muñoz Maniega
A1 Maria Valdés Hernández
A1 Zoe Morris
A1 Sally John
A1 Paola G. Bronson
A1 Elliot M. Tucker-Drob
A1 John M. Starr
A1 Mark E. Bastin
A1 Joanna M. Wardlaw
A1 Adam S Butterworth
A1 Ian J. Deary
YR 2019
UL http://biorxiv.org/content/early/2019/07/04/692459.abstract
AB Identifying the biological correlates of late life cognitive function is important if we are to ascertain biomarkers for, and develop treatments to help reduce, age-related cognitive decline. This study investigated the associations between plasma levels of 91 neurology-related proteins (Olink® Proteomics) and general fluid cognitive ability in the Lothian Birth Cohort 1936 (LBC1936, N=798), the Lothian Birth Cohort 1921 (LBC1921, N=165), and the INTERVAL BioResource, (N=4,451). In LBC1936, we also examined mediation of protein-cognitive ability associations by MRI-derived indices of brain structure. In the LBC1936, 22 of the proteins and the first principal component (PC) created from a PC analysis of the 91 proteins, were associated with general fluid cognitive ability (β between −0.11 and −0.17, p<0.0029). Total brain volume partially mediated the association between 10 of these proteins and general fluid cognitive ability. Effect sizes for the 22 proteins, although smaller, were all in the same direction as in LBC1936 in an age-matched subsample of INTERVAL. Similar effect sizes were found for the majority of these 22 proteins in the older LBC1921. The associations were not replicated in a younger subset of INTERVAL. In conclusion, we identified plasma levels of a number of neurology-related proteins that were associated with general fluid cognitive ability in later life, some of which were mediated by brain volume.