RT Journal Article
SR Electronic
T1 HERV-K and HERV-W transcriptional activity in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 693465
DO 10.1101/693465
A1 Rodrigues, Lucas S
A1 Nali, Luiz H da Silva
A1 Leal, Cibele O D
A1 Sabino, Ester C
A1 Lacerda, Eliana M
A1 Kingdon, Caroline C
A1 Nacul, Luis
A1 Romano, Camila M
YR 2019
UL http://biorxiv.org/content/early/2019/07/05/693465.abstract
AB Chronic Fatigue Syndrome / Myalgic Encephalomyelitis (CFS / MS) is an incapacitating chronic disease that dramatically compromise the life quality. The CFS/ME pathogenesis is multifactorial, and it is believed that immunological, metabolic and environmental factors play a role. It is well documented an increased activity of Human endogenous retroviruses (HERVs) from different families in autoimmune and neurological diseases, making these elements good candidates for biomarkers or even triggers for such diseases. Here the expression of Endogenous retroviruses K and W (HERV–K and HERV–W) was determined in blood from moderately and severely affected ME/CFS patients. HERV-K was overexpressed only in moderately affected individuals and HERV-W showed no difference. This is the first report about HERV-K differential expression in moderate ME/CFS.