RT Journal Article
SR Electronic
T1 Competitive release in tumors
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 263335
DO 10.1101/263335
A1 Yongqian Ma
A1 Jeffrey West
A1 Paul K. Newton
YR 2018
UL http://biorxiv.org/content/early/2018/02/10/263335.abstract
AB Competitive release is a bedrock principle of coevolutionary ecology and population dynamics. It is also the main mechanism by which heterogeneous tumors develop chemotherapeutic resistance. Understanding, controlling, and exploiting this important mechanism represents one of the key challenges and potential opportunities of current medical oncology. The development of sophisticated mathematical and computational models of coevolution among clonal and sub-clonal cell populations in the tumor ecosystem can guide us in predicting and shaping various responses to perturbations in the fitness landscape which is altered by chemo-toxic agents. This in turn can help us design adaptive chemotherapeutic strategies to combat the release resistant cells.