PT - JOURNAL ARTICLE AU - Erin C. Conrad AU - John M. Bernabei AU - Lohith G. Kini AU - Preya Shah AU - Fadi Mikhail AU - Ammar Kheder AU - Russell T. Shinohara AU - Kathryn A. Davis AU - Danielle S. Bassett AU - Brian Litt TI - How sensitive is functional connectivity to electrode resampling on intracranial EEG? Implications for personalized network models in drug-resistant epilepsy AID - 10.1101/696476 DP - 2019 Jan 01 TA - bioRxiv PG - 696476 4099 - http://biorxiv.org/content/early/2019/07/09/696476.short 4100 - http://biorxiv.org/content/early/2019/07/09/696476.full AB - Focal epilepsy is a clinical condition arising from disordered brain networks. Network models hold promise to map these networks, localize seizure generators, and inform targeted interventions to control seizures. However, incomplete sampling of epileptic brain due to sparse placement of intracranial electrodes may profoundly affect model results. In this study, we evaluate the robustness of several published network measures applied to intracranial electrode recordings and propose an algorithm, using network resampling, to determine confidence in model results. We retrospectively subsampled intracranial EEG data from 28 patients who were implanted with grid, strip, and depth electrodes during evaluation for epilepsy surgery. We recalculated global and local network metrics after both randomly and systematically resampling subsets of intracranial EEG electrode contacts. We found that sensitivity to incomplete sampling varied significantly across network metrics, and that this sensitivity was independent of the distance of removed contacts from the seizure onset zone. We present an algorithm, using random resampling, to compute patient-specific confidence intervals for network localizations on both global and nodal network statistics. Our findings highlight the difference in robustness between commonly used network metrics and provide tools to assess confidence in intracranial network localization. We present these techniques as an important step toward assessing the accuracy of intracranial electrode implants and translating personalized network models of seizures into rigorous, quantitative approaches to invasive therapy.