RT Journal Article
SR Electronic
T1 Bridging micro and macro: accurate registration of the BigBrain dataset with the MNI PD25 and ICBM152 atlases
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 561118
DO 10.1101/561118
A1 Yiming Xiao
A1 Jonathan C. Lau
A1 Taylor Anderson
A1 Jordan DeKraker
A1 D. Louis Collins
A1 Terry Peters
A1 Ali R. Khan
YR 2019
UL http://biorxiv.org/content/early/2019/07/09/561118.abstract
AB Brain atlases that encompass detailed anatomical or physiological features are instrumental in the research and surgical planning of various neurological conditions. Magnetic resonance imaging (MRI) has played important roles in neuro-image analysis while histological data remain crucial as a gold standard to guide and validate such analyses. With cellular-scale resolution, the BigBrain atlas offers 3D histology of a complete human brain, and is highly valuable to the research and clinical community. To bridge the insights at macro- and micro-levels, accurate mapping of BigBrain and established MRI brain atlases is necessary, but the existing registration is unsatisfactory. The described dataset includes co-registration of the BigBrain atlas to the MNI PD25 atlas and the ICBM152 2009b atlases (symmetric and asymmetric versions) in addition to manual segmentation of the basal ganglia, red nucleus, and hippocampus for all mentioned atlases. The dataset intends to provide a bridge between insights from histological data and MRI studies in research and neurosurgical planning. The registered atlases, anatomical segmentations, and deformation matrices are available at: https://osf.io/xkqb3/.