PT  - JOURNAL ARTICLE
AU  - Robersy Sanchez
AU  - Xiaodong Yang
AU  - Hardik Kundariya
AU  - Jose R Barreras
AU  - Yashitola Wamboldt
AU  - Sally A. Mackenzie
TI  - Enhancing resolution of natural methylome reprogramming behavior in plants
AID  - 10.1101/252106
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 252106
4099  - http://biorxiv.org/content/early/2018/02/14/252106.short
4100  - http://biorxiv.org/content/early/2018/02/14/252106.full
AB  - We have developed a novel methylome analysis procedure, Methyl-IT, based on information thermodynamics and signal detection. Methylation analysis involves a signal detection problem, and the method was designed to discriminate methylation regulatory signal from background noise induced by thermal fluctuations. Comparison with three commonly used programs and various available datasets to furnish a comparative measure of resolution by each method is included. To confirm results, methylation analysis was integrated with RNAseq and network enrichment analyses. Methyl-IT enhances resolution of genome methylation behavior to reveal network-associated responses, offering resolution of gene pathway influences not attainable with previous methods.